Principal Scientist, Computational Biology

Principal Scientist, Computational Biology

Do you have the passion to join a young global biopharmaceutical whose sole mission is to improve the lives of patients bravely facing cancer? Does it excite you to be a part of a rapidly expanding company with multiple marketed products and a diverse and robust pipeline? If yes, you may be a great fit for our community of dedicated and innovative associates.

Your impact at TESARO:

The Principal Scientist, Computational Biology will be a vital member of the growing Cancer Computational Biology group supporting Translational Research & Development programs, and providing experienced organizational, technological and scientific leadership in the application of state of the art computational biology and bioinformatics approaches in drug and biomarker development. A crucial component will be the establishment of a high quality and collaborative expertise in data mining, text mining, data analysis, data visualization, computer programming, and computational biology applied across the TESARO portfolio.

Job Responsibilities:

* Access, analyze and integrate publicly available oncogenomics information to enable preclinical experimental design for research teams.

* Bring in expertise in statistics, mathematics and computer science to enhance our computational biology capabilities; lead the discussion on rigorous statistic methods and novel computational and system biology algorithms in the computational biology group.

* Work with external resources to generate and analyze tumor genome / transcriptome profiling data for pre-clinical models; integrate with internal and external large scale non-clinical and clinical data sets to understand mechanism of compound response, aimed to inform additional patient selection / enrichment marker development, additional indications, and rational combination strategies.

* Enable new asset diligence from cancer informatics perspectives: integrate cancer genomic data to help evaluate new targets and agents.

Requirements:

* Ph.D. or equivalent computational/statistical experience and training with 5 years of applied experience in Pharma/Biotech; oncology and oncogenomics experience preferred.

* Experience in large scale, multi-dimensional genomic (including but not limited to NGS) data analysis, integration and management, with proficiency in data visualization.

* Proven ability to collaborate and influence across multi-disciplinary teams of internal colleagues and interact with external experts in academic institutions as well as CROs.

* A high level of integrity and desire to find new medicines that bring benefit to patients; a strong intellectual curiosity and desire to understand and solve problems; a willingness to work pro-actively in a fast-paced and dynamic work environment.

* Flexibility to work with internal and external systems, especially cloud based computing and storage infrastructure; AWS experience desired.

* Creative and practical use of systems biology methods in gene/target discovery, interpretation of cellular processes, and biomarker discovery.

TESARO is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.

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