Senior Scientist/Principal Scientist - Tumor Immune Biology (In vivo)
US-BI Pharma/BI USA
 Ridgefield, CT

Candidate will be hired at level commensurate with experience

and education

Description:

A key scientific staff member of the

Cancer Immunology and Immune Modulation (CI&IM) Research Group at

Boehringer Ingelheim’s US research facility in Ridgefield, CT, the successful

candidate will lead research efforts focusing on novel animal models for cancer

immunotherapy drug discovery and in vivo mechanism of action (MOA) studies to

support target validation, candidate selection and biomarker discovery of novel

immune-based concepts for cancer and inflammation therapy at BI.

As an employee of Boehringer

Ingelheim, you will actively contribute to the discovery, development and

delivery of our products to our patients and customers. Our global presence

provides opportunity for all employees to collaborate internationally, offering

visibility and opportunity to directly contribute to the companies' success. We

realize that our strength and competitive advantage lie with our people. We

support our employees in a number of ways to foster a healthy working

environment, meaningful work, diversity and inclusion, mobility, networking and

work-life balance. Our competitive compensation and benefit programs reflect

Boehringer Ingelheim's high regard for our employees.

Duties & Responsibilities:

  • Develop, establish and coordinate innovative in vivo
    model development to evaluate the stromal and immune modulatory effects of
    new therapeutic concepts (NTCs), for anti-tumor efficacy demonstration and
    candidate selection, as well as to explore MOA and biomarkers.
  • Independently drive in vivo and ex vivo studies for
    multiple research programs across the different stages of preclinical drug
    discovery and advancement of BI’s oncology pipeline.
  • Independently responsible for authoring animal
    protocols and ensuring their authorization and compliance.
  • Train and direct research scientists - may have
    supervisory responsibilities as needed including recruiting, managing,
    mentoring and developing scientific staff.
  • Collaborate extensively with other members of the
    Cancer Immunology and Immune Modulation Group in Ridgefield and globally
    for protocol development and execution of studies, while synergizing
    effectively with the in vivo pharmacology group in the Inflammation &
    Respiratory therapeutic area.
  • Prepare and review clear and accurate technical and
    research reports for internal and external use. Prepare and deliver scientific
    presentations for internal/external use. Act as an experienced resource in
    project teams, and demonstrate clear and professional verbal and written
    communication.
  • Continue to develop scientific expertise, credentials
    and drug development expertise by keeping abreast of relevant literature,
    by expanding scientific/technical knowledge and skill sets, and by
    publishing in peer-reviewed journals and speaking at
    internationally-recognized scientific conferences.

Senior Scientist Requirements:

  • PhD from an accredited institution or
    equivalent experience in a related field.
    Post-doctoral
    fellowship work experience is highly desired.

Principal Scientist Requirements:

  • PhD with a minimum of 5 years of
    post-doctorate training and/or industrial experience.
  • Proven track record of supervising
    scientists and students.

Requirements for both levels:

  • Strong understanding of cancer
    immunity, including myeloid and fibroblastic components of the tumor
    microenvironment and stroma and their influence on T cell biology.
  • Strong understanding of mouse immunology
    and cancer immunology, with exceptional in vivo experimental skills. Prior
    hands-on experience with mouse models of immunotherapy (e.g. syngeneic
    mouse tumor models, genetically-engineered mouse tumor models) and
    developing novel in vivo models to assess the effects of novel therapeutic
    concepts are a must. Experience with efficacy and
    pharmacokinetic/pharmacodynamics (PK/PD) and biomarker studies is a plus.
  • A demonstrated track record of
    independent research and peer-reviewed publications in areas of cancer
    immunology research. Familiarity with assessing the anti-tumor activity of
    cancer immunotherapeutics using humanized mouse models is a plus.
  • Excellent oral and written
    communication skills, with the ability to propose, articulate, evaluate
    and defend scientific ideas and data.
  • The ability to mentor and
    develop scientific staff
  • The ability and willingness to
    work effectively in a highly collaborative research environment - with
    colleagues in Germany, Austria and the USA including occasional travel to
    global research sites.
  • The ability to both conduct independent
    research and be a team player.
  • The ability to prioritize
    responsibility and be comfortable with changing direction/priorities.

Eligibility

Requirements:

Must be legally

authorized to work in the United States without restriction.

Must be willing to

take a drug test and post-offer physical (if required)

Must be 18 years of

age or older

Who We Are:

At Boehringer Ingelheim we create value through innovation

with one clear goal: to improve the lives of patients. We develop breakthrough

therapies and innovative healthcare solutions in areas of unmet medical need

for both humans and animals. As a family owned company we focus on long term

performance. We are powered by 50.000 employees globally who nurture a

diverse, collaborative and inclusive culture. Learning and development for

all employees is key because your growth is our growth.

Want to learn more?

Visit boehringer-ingelheim.com

and join us in our effort to make more health.

Boehringer Ingelheim, including Boehringer Ingelheim

Pharmaceuticals, Inc., Boehringer Ingelheim USA, Boehringer Ingelheim Animal

Health USA Inc., Boehringer Ingelheim Animal Health Puerto Rico LLC and

Boehringer Ingelheim Fremont, Inc. is an equal opportunity and affirmative

action employer committed to a culturally diverse workforce. All qualified

applicants will receive consideration for employment without regard to race;

color; creed; religion; national origin; age; ancestry; citizenship status,

marital, domestic partnership or civil union status; gender, gender identity or

expression; affectional or sexual orientation; pregnancy, childbirth or related

medical condition; physical or psychiatric disability; veteran or military

status; domestic violence victim status; genetic information (including the

refusal to submit to genetic testing) or any other characteristic protected by

applicable federal, state or local law.

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