Senior Scientist/Principal Scientist - Quantitative Systems Pharmacology Modeling
US-BI Pharma/BI USA
 Ridgefield, CT

Candidate will be hired at level commensurate with experience and education


Description:


A key scientific staff member of the Biotherapeutics Discovery Group at Boehringer Ingelheim’s US research facility in Ridgefield, CT, the successful Senior Scientist/Principal Scientist will design and implement mechanistic PK/PD and quantitative systems pharmacology models in support of Boehringer Ingelheim’s innovative pre-clinical New Biological Entity (NBE) R&D portfolio. Represent the PK/PD modeling discipline on multi-disciplinary teams and integrate PK/PD considerations into team strategy. Collaborate with key stakeholders in pre-clinical and clinical development in support of the overall translational research strategy for projects. Enhance capabilities of group by implementing novel modeling approaches and technologies.

As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, diversity and inclusion, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees.


Duties & Responsibilities:

  • Independently develops pre-clinical PK/PD and quantitative systems pharmacology models that enhance decision making for NBE target and candidate selections and inform translational research strategies for NBEs
  • Uses modeling and simulation to predict human efficacious dose/dose regimen, and influences selection of first-in-human starting dose
  • Designs, analyzes and interprets quantitative pharmacology and pharmacokinetic data and communicates results to teams and management
  • Leverages literature data or proposes new experiments to validate models or test model-generated hypotheses
  • Develops new methodologies, protocols or procedures that contribute to core group/research goals and reflect expert knowledge
  • PK/PD modeling representative on multiple cross-functional project teams
  • Effectively collaborates with scientists within and outside functional area (e.g. therapeutic area biologists and molecule discovery scientists)
  • Prepares clear technical reports, publications and oral presentations
  • Develops broad knowledge in field of expertise and enhances internal capabilities of group
  • Presents work at internal/external scientific meetings and publishes work in scientific journals

Senior Scientist Requirements:

  • Ph.D. in Pharmacokinetics, Pharmaceutical sciences, Pharmacology or related discipline with proven track record of applying modeling and simulation approaches in academia or industry
  • Theoretical and practical knowledge of pharmacokinetics, PK/PD and quantitative systems pharmacology modeling

  • Experience using one or more commercially available modeling and simulation platforms (e.g. Phoenix/WinNonlin, ADAPT, NONMEM, MATLAB, SimBiology, etc.)

  • Experience in mechanism-based PK/PD modeling of therapeutic proteins is highly desired

  • Ability to build effective working relationships and influence others both inside and outside department

  • Strong aptitude for sharing expertise with cross-functional and global teams

  • Ability to communicate effectively both orally and in writing in an interdisciplinary environment

  • Committed to professional development of self and others

Principal Scientist Requirements:

  • Ph.D. in Pharmacokinetics, Pharmaceutical sciences, Pharmacology or related discipline with a minimum of 2 - 5 years of relevant academic or pharmaceutical industry experience. Proven track record of applying modeling and simulation approaches in academia or pharmaceutical industry

  • Theoretical and practical knowledge of pharmacokinetics, PK/PD and quantitative systems pharmacology modeling

  • Experience using one or more commercially available modeling and simulation platforms (e.g. Phoenix/WinNonlin, ADAPT, NONMEM, MATLAB, SimBiology, etc.)

  • Experience in mechanism-based PK/PD modeling of therapeutic proteins is highly desired

  • Prior experience supervising, mentoring and developing scientific staff

  • Ability to build effective working relationships and influence others both inside and outside department

  • Strong aptitude for sharing expertise with cross-functional and global teams

  • Ability to communicate effectively both orally and in writing in an interdisciplinary environment

  • Committed to professional development of self and others

Eligibility Requirements:

  • Must be legally authorized to work in the United States without restriction.
  • Must be willing to take a drug test and post-offer physical (if required)
  • Must be 18 years of age or older

Who We Are:

At Boehringer Ingelheim we create value through innovation with one clear goal: to improve the lives of patients. We develop breakthrough therapies and innovative healthcare solutions in areas of unmet medical need for both humans and animals. As a family owned company we focus on long term performance. We are powered by 50.000 employees globally who nurture a diverse, collaborative and inclusive culture. Learning and development for all employees is key because your growth is our growth.

Want to learn more? Visit boehringer-ingelheim.com and join us in our effort to make more health.

Boehringer Ingelheim, including Boehringer Ingelheim Pharmaceuticals, Inc., Boehringer Ingelheim USA, Boehringer Ingelheim Animal Health USA Inc., Boehringer Ingelheim Animal Health Puerto Rico LLC and Boehringer Ingelheim Fremont, Inc. is an equal opportunity and affirmative action employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; citizenship status, marital, domestic partnership or civil union status; gender, gender identity or expression; affectional or sexual orientation; pregnancy, childbirth or related medical condition; physical or psychiatric disability; veteran or military status; domestic violence victim status; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by applicable federal, state or local law.

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