Technical Expert (PBPK)
Jobs across Syngenta
 Greensboro, NC

About Syngenta


is a leading agriculture company helping to improve global food security by enabling

millions of farmers to make better use of available resources. Through world

class science and innovative crop solutions, our 28,000 people in over 90

countries are working to transform how crops are grown. We are committed to rescuing land from

degradation, enhancing biodiversity and revitalizing rural communities.

About this Job:


at our Greensboro site, you will be part of our North America Human Safety

team. We are looking for a key

scientific contributor within the Human Safety function of Product Safety and

providing pharmacokinetic expertise to project teams, toxicologists and other

functional areas as required. You will

be responsible for protocol design, input for hypothesis-driven pharmacokinetic

/ toxicokinetic studies, evaluating data, and authoring company reports.


will enjoy working with other scientific functions, being the subject matter

expert, sharing your knowledge and guiding colleagues to address PBPK and

ADME-related issues, and provide guidance on the appropriate use of these data

for decision making purposes about compound progression.

We are looking for an experienced scientist who will

to take responsibility for the design, conduct and interpretation of

mechanistic in vivo and in vitro pharmacokinetic studies. Employing preclinical PBPK/PD models for the

establishment of concentration-effect relationships, including in vitro to in vivo extrapolation and the projection of human exposure profiles

to aid in the early identification of possible development risks and/or

opportunities for improvements in risk assessments.

Essential Duties &


  • Manage studies placed
    with external suppliers to ensure delivery of data of the appropriate
    quality to time and cost
  • Coordinate the delivery
    of studies conducted internally or externally to ensure project needs are
  • Independently provide
    technical assistance to external suppliers, where appropriate, to
    facilitate transfer of technical know-how
  • Using your knowledge and
    expertise, interpret the data ensuring the appropriate questions have been
    answered and communicate the meaning of data and its implication to the
  • Through participation in
    project teams contribute to key decisions and aid compound selection
  • Work with colleagues in
    other functions to support the use of ADME data sets to optimize
    toxicology study design and overall understanding of the compound’s
    behavior in vivo
  • Identify opportunities
    for improvement/further development of existing capability, e.g. in vitro to in vivo extrapolation, use of in silico tools, and PBPK models

Education &


  • Requires a PhD (or
    equivalent work experience) in biological or chemical sciences
  • A fundamental
    understanding of compound discovery and development in an industrial
    setting and the utility of pharmacokinetics in this process
  • Background knowledge of
    mammalian toxicology studies and objectives
  • Training and hands-on
    experience in pharmacokinetics and basic knowledge in mechanistic PK/PD
    (TK/TD) modelling and an ability to design, supervise, and interpret
    various types of mechanistic ADME/PK and TK studies
  • Proficiency in the
    development/optimization of new/existing experimental models to support
    hypothesis-driven pharmacokinetic research
  • Prior experience with PK
    analysis (non-compartment & multi-compartment modelling) and a
    demonstrated ability to work with modelling tools (e.g., NONMEM, Phoenix,
    GastroPlus, Simcyp)
  • Experience working in
    multi-disciplinary project teams
  • Experience accessing
    services through third-party organizations

What We Offer:

  • Full Benefit Package
    (Medical, Dental & Vision) that starts your first day
  • 401k plan with company
    match, Profit Sharing & Retirement Savings Contribution
  • Paid Vacation, 12 Paid
    Holidays, Maternity and Paternity Leave, Education Assistance, Wellness
    Programs, Corporate Discounts among others
  • A culture that promotes
    work/life balance, celebrates diversity and offers numerous family oriented
    events throughout the year


is an Equal Opportunity Employer and does not discriminate in recruitment,

hiring, training, promotion or any other employment practices for reasons of

race, color, religion, gender, national origin, age, sexual orientation, gender

identity, marital or veteran status, disability, or any other legally protected



Contact Information:


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Employment Opportunity Commission's (EEOC)



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