Postdoctoral Associate

University of Florida Gainesville, FL
Classification Title:

Postdoctoral Position

Job Description:

Postdoctoral Positions Available

Welcome! Multiple postdoctoral positions areavailable in the Department of Oral Biology in the College of Dentistry asnoted below. Applicants should have earned a PhD, or PhD along with a DMD/DDS,MD, or DVM degree, by time of hire. For details on faculty mentors and projects, pleasevisit: http://dental.ufl.edu/departments/oral-biology/postdoc-assoc-positions-available/

The review of applications will begin immediately and will continue until allpositions are filled. The University of Florida is an equal opportunityinstitution dedicated to building a broadly diverse and inclusive workenvironment.

Laboratoryof Dr. Robert A. Burne

Multiple postdoctoral positions are available to study generegulation, genomics and physiology of pathogenic, commensal and/or beneficialoral streptococci. Projects include use of planktonic, biofilm, andmicrofluidic model systems to analyze modulation of intercellular communicationsystems by peptides and other small effector molecules, and by environmentalinputs that include pH, carbohydrate source and oxygen. Other projects involveexploration of the genetic and genomic basis for expression by commensal oralstreptococci of properties that are beneficial to their host and antagonisticto pathogenic species.

MyNCBI Collections:

Laboratory of Dr. Sang-Joon Ahn

Our research focuses on understanding of how the dental cariespathogen treptococcus mutans persists in biofilms that harbor a highly complexpopulation of differentiated cells and dynamic metabolic processes using invitro and in vivo approaches, and further establishing a link between biofilmdevelopment and cell death/lysis. (Project number: 1R01DE025237)

MyNCBI Collections:

Dr. L. Jeannine Brady Laboratory

Work in the Brady Lab is directed at understanding mechanisms ofmembrane and cell surface biogenesis in the cariogenic pathogen Streptococcusmutans. The functional interactions and respective roles ofcomponents of the co-translational signal recognition particle (SRP) pathway andthe YidC1 and YidC2 chaperone-insertases in membrane protein insertion arebeing evaluated with an emphasis on competence development and mutacinproduction. In addition, S. mutans has been found to producefunctional amyloids that influence biofilm development and that can serve astargets for therapeutic anti-amyloid compounds. Study is currentlydirected at elucidating the structural basis and environmental control ofamyloid fibrillization in in vitro and in vivo systems. Furthermore, S. mutans is capable of releasing DNA into theextracellular environment via membrane vesicles. The contribution ofvesicle-released eDNA to biofilm formation and its functional interactions withbacterial cells and extracellular matrix components are under study. Post-doctoralcandidates will be considered to evaluate development and stabilization ofbiofilm matrices related to amyloid formation and should have demonstratedexpertise in the characterization of protein-protein and protein-nucleic acidinteractions, in protein structure analysis, particularly by solid state NMR,and/or in electron and confocal microscopy.

MyNCBI Collections:

Laboratory of Dr. Mary Ellen Davey

The Davey lab uses a combination of genetics, bacterialphysiology, and gene expression analysis (RNA-seq and qPCR) to study theinterrelationship between biofilm development and the pathogenicity of the oralanaerobe, Porphyromonas gingivalis. In particular, we are focusedon molecular mechanisms that control changes in expression of cell surfacestructures, including capsular polysaccharides, sphingolipids, and fimbriae;and the subsequent impact on the interaction of P. gingivalis with hostcells. (Project numbers: 2 R01 DE019117 07; and 1 R01 DE024580 01A1)

MyNCBI Collections:

Laboratory of Dr.Lemos and Dr.Abranches

The Lemos-Abranches lab uses genetics, biochemistry,transcriptomic and metabolomic approaches to characterize the molecular factorsthat mediate virulence in opportunistic Gram-positive pathogens such as Streptococcusmutans and Enterococcus faecalis. In S. mutans, a majorpathogen in dental caries and a leading causative agent of infectiveendocarditis, our current efforts focus on the characterization of theoxidative stress regulator Spx and its role in controlling stress responses andbiofilm formation. The second S. mutans project focuses on thecharacterization of a collagen binding protein responsible for intracellularinvasion of heart and oral tissues, a trait that is linked to increasedvirulence and, potentially, recurrent infection and chronic inflammation. Thecharacterization of stress responses is also the theme of our research with E.faecalis, a leading cause of hospital-acquired infections. In this project,we are investigating the interplay between the stringent response, a majorbacterial stress response mechanism for adaptation to changing environments,with other prominent stress regulators and how these interactions influence theability of E. faecalis to survive antibiotic stress and other adverseconditions.

MyNCBI Collections (Lemos):

MyNCBI Collections (Abranches):

Advertised Salary:

Minimum starting annual salary $47,476; commensurate with qualifications and experience.

Minimum Requirements:

Applicants should have earned a PhD, or PhD along with a DMD/DDS, MD, or DVM degree, by time of hire.

Preferred Qualifications:

Individuals with expertise in bacterial genetics and gene expression; genome-scale analysis of the microbiome; microbial pathogenesis; host:microbiome interactions; microbial biofilms; bioinformatics; interbacterial interactions; protein translocation and structural biology; diabetes; chronic inflammation; and/or host responses to pathogenic, commensal and beneficial microorganisms are sought.

Special Instructions to Applicants:

Applicants should submit a cover letter, CV, and the names and contact information for three references.

Final candidate will be required to provide official transcript to the hiring department upon hire. A transcript will not be considered "official" if a designation of "Issued to Student" is visible. Degrees earned from an education institution outside of the United States are required to be evaluated by a professional credentialing service provider approved by National Association of Credential Evaluation Services (NACES), which can be found at http://www.naces.org/.

Health Assessment Required:

Yes