Sr Scientist/Process Engineer- PD/Tech Transfer

Intellia Therapeutics Cambridge, MA
At Intellia, we are revolutionizing medicine by harnessing the power of genome editing to develop potential cures. We bring new hope for people living with conditions including cancer, genetic disorders, viral infections, inflammatory disorders and many more.

The ideal applicant will be an experienced Senior Scientist with a strong background in lipid nanoparticle (LNP) based delivery platforms and will have an excellent track record of process development including scale up for GMP manufacturing as well as familiarity with drug product analytics. The primary near-term responsibility of this position will be to oversee technical transfer of our lead LNP formulation process to contract manufacturers. This will include active participation with both CMO and internal PD around ongoing scaleup, improvements, and troubleshooting. Oversight of the expected GMP campaigns at the US based CMO is also essential. Longer term responsibilities will also include involvement with current PD work and GMP preparation activities for key intermediates supporting the manufacture of LNPs. In a broader sense, the successful candidate will show leadership in several of the following; the process scale up and clinical development of innovative LNP and viral vector technologies for the in vivo delivery of complex biological molecules including ribonucleic acid, protein and dsDNA for the therapeutic application of CRISPR/Cas9 gene editing technology. A strong understanding of the necessary analytics to support key decision making for process and formulation process changes will be essential.

General Responsibilities:

* Drive clinical development of CRISPR/Cas9 therapeutic delivery formulation programs.

* Scale up drug product formulation processes and transfer to CMOs.

* Oversee GMP manufacturing of drug product and critical formulation components.

* Explore and develop novel processes for producing both in vivo and ex vivo therapeutic drug products as well as improving COGS for Intellia product candidates and intermediates.

* Develop intellectual property, publishing scientific papers, and other tasks related to the company's scientific and business interests.

* Mentor and influence Research Associates in the group.

Required Skills:

* Extensive experience with process scale up and technical transfer to CMOs for GMP production.

* Experience designing, developing and analyzing LNP based drug delivery systems.

* Effective inter-department, CMO and supply coordination to meet project goals and timelines.

* Proficiency with the spectrum of process tools and analytical techniques applicable to protein, nucleic acids, & LNPs

* Experience with production final fill technology

* Organized, detail-oriented, and a self-starter who continuously seeks innovative solutions.

* Excellent verbal and written communication skills.


* Ph.D. in Biological Sciences, Process Engineering or related discipline with at least 2 years of post-PhD experience, preferably in an industrial drug discovery setting preferred.

* Relevant MS with >8 years of industrial experience will also be considered.

* Track record of leading a team of scientists and research associates.

* Local candidates strongly preferred.

What Intellia Stands For?

At Intellia, our mission is to develop potentially curative genome editing treatments that can positively transform the lives of people living with severe and life-threating diseases.

We push boundaries. We are focused on positively disrupting health care treatment of patients with genomic diseases. The values we live by and drivers we look for are:

* One is respect for individuals; our unique qualities and strengths; our own ways to understand, learn and improve. One is our single-minded determination to excel; to succeed together. One is you and us – trusting and counting on every single one of us.

* Explore because we seek new ways to tackle disease. Explore with unbounded minds…free from assumptions, open to ideas. Explore by staying curious, by pushing boundaries, overcoming obstacles. Explore means thinking of new ways.

* Disrupt by thinking courageously…and creating a better future. Disrupt by defying conformity; interrogating the status quo; questioning our momentum. Disrupt with challenging thoughts…with that breed of skepticism that shows you have better solutions.

* Deliver with your focus on the objective and your determination to complete the task. Deliver by advancing relentlessly and by maintaining high standards…even when nobody is watching. Deliver by staying accountable and pulling your weight. Deliver because patients are counting on us to make the promise reality. Get it done.

POSITION: Full-Time, Exempt

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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