Senior/Principal Scientist, Oncology
Flagship Pioneering, Inc.
 Cambridge, MA

Senior/Principal Scientist, Oncology

Cambridge, MA 

Job Description

Company Summary
FL56, Inc. is a privately-held biotechnology company that is pioneering Generative Biology to bring control and intentionality to the development of medicines. FL56 has developed a proprietary, multi-product Generative Biology Engine to create potent biologics in multiple therapeutic modalities. FL56 was founded by Flagship Pioneering in the Flagship Labs innovation foundry. Flagship Pioneering creates, resources, and builds life science companies that invent breakthrough technologies in order to transform healthcare and sustainability. Flagship has created over 100 groundbreaking companies since 2000, including Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Indigo Agriculture and Sana Biotechnology.

Position Summary
VL56 is seeking to expand the Research & Development team by recruiting a talented Oncologist to play a leading role in the development of the Oncology/Immuno-oncology program. This position will be responsible for assay development and design of experimental approaches to assess FL56’s proprietary biomolecules, as well as to help guide and develop the overall strategic approach of the Oncology group. The successful candidate will work alongside our team of world-class scientists in a dynamic, fast-paced environment to both develop key components of the platform and validate our proprietary design capabilities to rapidly advance our technology. A successful candidate should be able to demonstrate both an aptitude to immediately contribute in the lab and support the pipeline development of novel biologics in the oncology and immuno-oncology therapeutic space.  We are searching for an enthusiastic, innovative, well-organized and highly-motivated individual who is comfortable working in a fast-paced, entrepreneurial environment.


Key Responsibilities


  • Generate hypotheses and design experimental plans to validate and further define the role of the properties of VL56’s proprietary biomolecules in vitro and in vivo

  • Develop a pipeline of novel biologics in the oncology and immuno-oncology therapeutic space

  • Execute experiments, generate robust data packages, perform incisive analysis and communicate data to scientific team and executive management to achieve company objectives

  • Collaborate with experienced team members in the Generation Engine and Protein Engineering functions to further understand the biology around the targets and progress drug discovery efforts

  • Assist with establishment and expansion of internal wet lab capabilities and relationships with external CROs and collaborators to drive projects from discovery to clinical entry

  • Help to develop the scientific strategy of the oncology group and identify new opportunities for machine learning in oncology/immuno-oncology

  • Maintain up-to-date knowledge on current literature and advances in the field of oncology/immuno-oncology


Experience and Qualifications


  • Ph.D. in Immunology, oncology or related field with 5+ years of laboratory experience from the biotech/pharma industry and/or academic setting 

  • Deep technical expertise and master of associated lab techniques; strong experience with protein-based immunotherapies, molecular biology, preclinical cancer models, immunological techniques and signal transduction pathways

  • Familiarity with computational and/or protein engineering techniques a plus

  • Ability to parallel process multiple projects and modalities and support the growing portfolio

  • Excellent written and verbal communication skills including the ability to communicate results and biologic concepts clearly to others not familiar with the field to allow for collaboration

  • Creates a learning environment, open to suggestions and experimentation for improvement

  • Ability to work independently as well as to collaborate with peers