Scientist I (R&D)
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location: Cambridge, Massachusetts
job type: Contract
salary: $30 - 38 per hour
work hours: 9 to 5
This role requires employees to be fully vaccinated against COVID-19 as a condition of employment, subject to a valid medical or religious accommodation.
Neurodegenerative Disease Research Unit (NDRU) is seeking an enthusiastic, detail oriented, and highly motivated scientist to join our team and contribute to drug discovery programs for Alzheimer's disease. NDRU is driving innovation on early drug discovery and laying the translational framework for novel mechanisms to be brought forward into clinical interrogation with the goal of generating pioneering therapeutics for neurological diseases.
The ideal candidate will have hands-on experience in a variety of molecular, cellular, and biochemical assays as well as immunohistochemistry techniques using pathology markers to utilize in vivo and in vitro models relevant for Alzheimer's disease for target validation and support for drug discovery projects. The selected individual is expected to plan and execute experiments, rigorously analyze, and interpret the results with limited supervision to achieve project objectives in addition to frequently communicating results to project leaders, collaborating in a team-focused environment, and presenting findings in cross functional project teams.
- Contribute to preclinical projects by designing, executing, analyzing, and troubleshooting molecular, cellular, and biochemical assays using brain tissue from preclinical models for Alzheimer's disease (qPCR, ELISA, HTRF, WB, etc.) with limited supervision.
- Collect brain tissue from transgenic mice and perform immunohistochemistry using pathology markers.
- Perform physiologically relevant cellular assays in disease models of iPSC-derived neurons for target validation purposes.
- Establish and adapt new experimental protocols.
- Document experiments, maintain electronic laboratory notebooks, and present data to the team.
- Bachelor's or Master's degree in relevant discipline (e.g. neurobiology, cell/molecular biology, biochemistry, etc.).
- Experience in biotech/pharmaceutical industry or equivalent experience in academic laboratories.
- In vivo technical skills including animal handling, tissue collection, and immunohistochemistry.
- Hands-on experience working with in vivo models including genetically engineered models
- Experience with mammalian cell culture, including cell lines, primary cells, and iPSC derived models relevant to neurodegenerative disease research as applied to target discovery, validation, and cellular proof-of-action.
- Strong skillset in molecular biology techniques and various gene expression, immunoassay, and molecular profiling approaches applied to cells and brain tissues (e.g. qPCR, ELISA, WB, etc.).
- Ability to design, execute, and analyze experiments with limited supervision.
- Strong critical thinking, communication, organization, and presentation skills.
skills: Molecular Biology, PCR, Assay Development, Assay Method, Assay Verification, In Vitro, In Vivo, RT-PCR
For certain assignments, Covid-19 vaccination and/or testing may be required by Randstad's client or applicable federal mandate, subject to approved medical or religious accommodations. Carefully review the job posting for details on vaccine/testing requirements or ask your Randstad representative for more information.
Equal Opportunity Employer: Race, Color, Religion, Sex, Sexual Orientation, Gender Identity, National Origin, Age, Genetic Information, Disability, Protected Veteran Status, or any other legally protected group status.