Cell Processing Specialist

Dana-Farber Cancer Institute Boston, MA
Overview

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

Novel Cell Therapy Lab Cell Processing Specialists perform human cell processing, manufacturing, cryopreservation, product labeling, storage and transportation in the Cell Manipulation Core Facility (CMCF).

All work is performed in a Class 10,000 clean room environment; therefore, they must be familiar with aseptic technique, clean room procedures and cGMP requirements. Limited access to patients.

Responsibilities include the performance of highly technical and complex cellular and immunotherapeutic procedures including, but not limited to: cell purification, controlled rate freezing, cell culture and expansion. Cellular products arise from bone marrow. Cell culture experience is preferred.

The CMCF is gearing up to begin a large clinical trial and is hiring additional staff specifically for this project. This position is temporary to support this project which has an expected duration of approximately two and a half years dependent on enrollment. Must be available to work off-shift and weekends dependent on patient processing requirements.

Responsibilities

* Process human therapeutic cellular products by various methods using aseptic technique in a clean room environment.

* Perform procedures consistently according to standard operating procedures.

* Accurately and reproducibly generate expected results within established turnaround times.

* Achieve and maintain competency in routine procedures including:

* cell culture,

* cryopreservation/thawing,

* centrifugation and washing,

* labeling and transportation.

* Review and evaluate test results for acceptability including automated and manual cell counts, viability results, flow cytometry histograms, sterility testing results.

* Maintain records of procedures and resultant data, both manually and on computer.

* Enter data correctly in electronic data capture systems.

* Evaluates/troubleshoot problems related to product analysis and preparation. Appropriately communicates with project lead and with project sponsor, as required.

* Perform environmental monitoring of work area and laboratory.

* Communicate effectively and professionally with other health care providers involved in the patient's care.

* Detect, troubleshoot, and correct instrument, reagent, and system failures.

* Perform preventive and corrective maintenance of equipment and instrumentation. Identify the need for repair or referral as required.

* Respond to REES alarm system alerts and document corrective actions appropriately.

* Maintain a safe and professional working environment.

* Other duties and procedures as required or assigned.q

* Perform and document QC/QA activities as defined in policies & SOPs.

* Recognize and report deviations from standard operating procedures.

* Participate in validation of new instruments & methods.

* Examine existing processes and problems and continuously look for process improvement.

* Perform competency testing as required.

* Work within the cGMP and cGTP guidelines and adhere to all regulatory standards within the Cell Manipulation Core Facility

* Ability to apply critical decision-making skills during processing when required.

* Write and review standard operating procedures.

* Initiate and document corrective actions when required.

* Actively pursues continuing education opportunities.

Qualifications

* BS/BA in a Biological Science, Medical Technology or related field. Minimum 3 years experience in a clinical laboratory setting.

* Must be available to work off-shift and weekends dependent on patient processing requirements.

* Requires ongoing commitment to upgrade job skills.

* Able to work closely with others and possess solid interpersonal and communication skills.

* Capable of working in a fast-paced and rapidly changing environment.

* Effective in a small ethnically diverse work group.

* Capable of producing accurate results within strict time constraints.

* Must possess good judgment, problem solving and analytical skills.

* Ability to be flexible & adaptable to changing technology.

* Attention to detail and interpersonal skills to effectively communicate with staff and physicians.

* Good analytical reasoning & ability to perform complex mathematical calculations using scientific notation.

* Clinical/research GCP knowledge.

* Knowledge of lab safety and infection control.

* Familiarity with operation & performance of basic lab equipment, i.e., centrifuge, microscopes, etc.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.

Similar jobs you might like